Traffic pollution causes genetic changes in the womb which increase a child’s risk of developing asthma, a research from the Center for Environmental Genetics at the University of Cincinnati suggests.
The study of umbilical cord blood from 56 children found “reprogramming” of a gene called ACSL3, associated with exposure to compounds in traffic fumes. The gene was associated with asthma symptoms at age five.
The researchers recorded the mothers’ exposure to polycyclic aromatic hydrocarbons (PAHs) – a by-product of combustion present in high levels in heavy-traffic areas during their pregnancy with backpack air monitors. They found a significant association between chemical changes which control activation of the gene and high levels of maternal PAH exposure.
Experts say this is the first time pollution has been shown to influence genes.
Source: BBC News, 15 February 2009
Chapter: Asthma :: 16 March 2009
